TWO people have died and three young people are in hospital following a horrific fire at a family home in Brisbane.

Emergency services were called to a two-storey brick home at Braken Ridge, in Brisbane's north, at 4am on Friday to find it well alight.

Queensland Fire and Rescue Inspector Paul Durston said firefighters battled extreme conditions.

"They did a tremendous effort to actually make entry and do a search inside and locate these people even though they were deceased," he said.

The dead man and woman were found upstairs in the main bedroom. Police believe they did not wake up to the fire and were in bed when they died.

Queensland Police Service Detective Inspector Graham Clark said three people in their late teens managed to jump from a window and escape.

"The two people were located in the main bedroom and as far as we know there was only the five people in the house at this stage," he said.

"The three younger ones actually jumped out of the second-storey window and did receive some injuries."

News Limited reported the young victims were a 17-year-old girl, her elder brother and his fiancée.

The teenage girl sustained serious burns to her face and chest while the other two had burns and cuts to their legs and feet from jumping out of the window.

Det Insp Clark said initial inquiries showed there were no suspicious circumstances but investigations were continuing.

When he spoke to the media on Friday morning, the cause of the blaze had not been found.

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